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Verdant Arc Home About Services How It Works Risks & Safety Research & Policy Contact Evidence, uncertainty & safety Ibogaine Effects Ibogaine is a plant-derived psychoactive alkaloid associated with intense acute experiences, possible withdrawal relief, and serious cardiac risk. This guide separates what is known, what is still uncertain, and why medical oversight matters. Verdant Arc is an independent resource on ibogaine effects, evidence, and safety. cautious context A grounded orientation A complex substance, not a simple reset Ibogaine is a complex indole alkaloid found primarily in the root bark of the iboga plant, Tabernanthe iboga , native to Central Africa. It is a psychoactive alkaloid with traditional use in ceremonial settings and an uncertain place in western medicine. Interest often centers on addiction treatment, particularly for opioid withdrawal and drug dependence. Yet the same pharmacology that attracts attention also makes careful screening and medical supervision essential. Multiple systems The proposed mechanism of action spans opioid systems, NMDA receptors, serotonin transporters, dopamine receptors, and other cellular mechanisms. No single pathway fully explains the experience. An acute window Reports commonly describe a 4–8 hour visionary phase, followed by fatigue and extended reflection. Acute effects can be psychologically intense and physically demanding. Real safety limits Ibogaine can lengthen the QT interval and trigger dangerous arrhythmias. Heart conditions, electrolyte imbalance, and medication interactions can make the risk substantially higher. Neurobiology can frame questions, but it cannot predict one person’s outcome. Brain chemistry Why craving and withdrawal are central questions Ibogaine acts on multiple neurotransmitter systems, including NMDA receptors, opioid receptors, serotonin transporters, and dopamine reuptake sites. Its neurobiological activity involves the central nervous system rather than a single

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